Clinical Indication ID & Name
B Cell Non-Hodgkin Lymphoma
Test Group
Haematology
Specialties
Test code
M95.1
Test name
Ig gene (heavy & light chain) rearrangement & hypermutation detection multiplex seq
Target genes
IGH, IGK, IGL
Test scope
Complex variant detection
Test method/ technology
Complex targeted mutation testing
Optimal Family Structure
n/a
Eligibility Criteria
Molecular assessment will aid diagnosis or management
Test code
M95.2
Test name
Ig gene (heavy & light chain) rearrangement & hypermutation detection NGS
Target genes
IGH, IGK, IGL
Test scope
Complex variant detection
Test method/ technology
Panel
Optimal Family Structure
n/a
Eligibility Criteria
Molecular assessment will aid diagnosis or management
Test code
M95.3
Test name
Ig rearrangement FISH
Target genes
IGH, IGK, IGL
Test scope
Structural variant detection
Test method/ technology
FISH
Optimal Family Structure
n/a
Eligibility Criteria
Where demonstration of rearrangements of IGH, IGK or IGL will aid with the diagnosis of a B cell lymphoma
Test code
M95.4
Test name
Multi-target NGS panel - small variant (EZH2)
Target genes
EZH2
Test scope
Small variant detection
Test method/ technology
Panel
Optimal Family Structure
n/a
Eligibility Criteria
Molecular assessment will aid diagnosis or management
Test code
M95.5
Test name
EZH2 copy number FISH
Target genes
EZH2
Test scope
Copy number variant detection to genomewide resolution
Test method/ technology
FISH
Optimal Family Structure
n/a
Eligibility Criteria
Molecular assessment will aid diagnosis or management
Test code
M95.6
Test name
Multi-target NGS panel - small variant (BTK, PLCG2)
Target genes
BTK, PLCG2
Test scope
Small variant detection
Test method/ technology
Panel
Optimal Family Structure
n/a
Eligibility Criteria
Lymphoid disorder receiving / planned to receive relevant targeted inhibitor (to predict sensitivity or explain resistance)
Test code
M95.7
Test name
WGS Germline and Tumour
Target genes
All including burden / signature
Test scope
All variant types
Test method/ technology
WGS
Optimal Family Structure
n/a
Eligibility Criteria
For paediatric patients only
Test code
M95.8
Test name
Multi-target NGS panel - structural variant (Ig)
Target genes
IGH, IGK, IGL
Test scope
Structural variant detection
Test method/ technology
Panel
Optimal Family Structure
n/a
Eligibility Criteria
Where demonstration of rearrangements of IGH, IGK or IGL will aid with the diagnosis of a B cell lymphoma
Test code
M95.9
Test name
Mutli-target NGS panel - copy number (EZH2)
Target genes
EZH2
Test scope
Copy number variant detection to exon level resolution
Test method/ technology
Panel
Optimal Family Structure
n/a
Eligibility Criteria
Molecular assessment will aid diagnosis or management
Commissioning group
n/a
Overlapping idications
n/a
Address for samples/request forms
North Thames GLH, Rare & Inherited Disease Genomic Laboratory
Specimen Reception, Level 5 Barclay House, 37 Queen Square,
London WC1N 3BH
Contact with queries
Supporting documents
Cancer WGS Clinician pack
Education resources
n/a
Service updates
n/a
Request form download
n/a
Consent record
See consent guidance in test request form
Sample requirements
See sample guidance in test request form