Clinical Indication ID & Name
In all tumours eligible for NTRK1/2/3 testing
Test Group
Solid Tumours (Adult)
Specialties
Test code
M244.1
Test name
FISH
Target genes
NTRK1/2/3
Test scope
Structural variant detection
Test method/ technology
FISH
Optimal Family Structure
n/a
Eligibility Criteria
To be performed in Salvage pathway and when samples are not suitable for panel testing or NGS panel testing has failed.
NB will be subject to close audit
Commissioning group
n/a
Overlapping idications
n/a
Address for samples/request forms
Please refer to the test request form.
Contact with queries
Supporting documents
n/a
Education resources
n/a
Service updates
n/a
Request form download
Form not available, please contact us to enquire.
Consent record
See consent guidance in test request form
Sample requirements
Sample Requirements Each sample must be sent labelled with 3 patient identifiers and must state the sample type clearly on the sample container. Sample Rejection Samples may be rejected for the following reasons: 1. Samples and request form do not show at least three identical patient identifiers 2. The sample is in the incorrect collection media 3. The request form is not sufficiently completed 4. The sample is not of sufficient volume 5. The sample is too old|Sample Storage and Volume Required: FFPE tissue sections – 3-4µm sections on unstained Apes slides with appropriate IHC/H&E slide for correlation. Please see referral form for an indication of how many slides to include for testing (additional slides are advised to enable repeat testing in case of suboptimal hybridisation). Storage, sample packing and transportation: N/A Patient/Clinician Instructions: N/A Factors affecting performance of test/interpretation of results: It is essential to include an H&E or appropriate immuno stained slide, where areas of tumour are not easily identifiable these should be clearly marked on the slide. Cases referred without an H&E/immuno slide will not be analysed until this is provided.