Clinical Indication ID & Name
Mesothelioma
Test Group
Solid Tumours (Adult)
Specialties
Test code
M5.1
Test name
CDKN2A copy number FISH
Target genes
CDKN2A
Test scope
Copy number variant detection to genomewide resolution
Test method/ technology
FISH
Optimal Family Structure
n/a
Eligibility Criteria
Diagnostic uncertainty re mesothelioma or benign or reactive mesothelial proliferation
Test code
M5.2
Test name
Multi-target NGS panel - structural variant (NTRK1, NTRK2, NTRK3)
Target genes
NTRK1, NTRK2, NTRK3
Test scope
Structural variant detection
Test method/ technology
Panel
Optimal Family Structure
n/a
Eligibility Criteria
Patient’s clinical status means they are eligible for an NTRK inhibitor in the event an NTRK rearrangement is detected
Test code
M5.3
Test name
Multi-target NGS panel - copy number variant (CDKN2A)
Target genes
CDKN2A
Test scope
Copy number variant detection to exon level resolution
Test method/ technology
Panel
Optimal Family Structure
n/a
Eligibility Criteria
Diagnostic uncertainty re mesothelioma or benign or reactive mesothelial proliferation
Commissioning group
n/a
Overlapping idications
n/a
Address for samples/request forms
North Thames GLH, Rare & Inherited Disease Genomic Laboratory
Specimen Reception, Level 5 Barclay House, 37 Queen Square,
London WC1N 3BH
Contact with queries
Supporting documents
Cancer WGS Clinician pack
Education resources
n/a
Service updates
n/a
Request form download
Consent record
See consent guidance in test request form
Sample requirements
See sample guidance in test request form