Clinical Indication ID & Name
Recurrent miscarriage with products of conception available for testing
Test Group
Core
Specialties
Test code
R318.1
Test name
N/A
Target genes
Genomewide
Test scope
n/a
Test method/ technology
Common aneuploidy testing
Optimal Family Structure
n/a
Eligibility Criteria
Recurrent miscarriage with products of conception available for testing – defined as three or more miscarriages.
Test code
R318.2
Test name
N/A
Target genes
Genomewide
Test scope
n/a
Test method/ technology
Microarray
Optimal Family Structure
n/a
Eligibility Criteria
Recurrent miscarriage with products of conception available for testing – defined as three or more miscarriages.
Commissioning group
Core
Overlapping idications
• R297 Possible structural chromosomal rearrangement - karyotype test should be used in parents of recurrent miscarriage where products of conception are not available for testing • R22 Fetus with a likely chromosomal abnormality after a second trimester loss where there are fetal anomalies and all third trimester fetal losses (IUD or stillbirth) or R21 Fetal anomalies with a likely genetic cause should be used in cases of second or third trimester intrauterine death or stillbirth • R318 Recurrent miscarriage (three or more consecutive miscarriages) with products of conception available for testing can be used where there has been recurrent miscarriage in the absence of additional features suggestive of chromosomal abnormality
Address for samples/request forms
Please refer to the test request form.
Contact with queries
Supporting documents
n/a
Education resources
n/a
Service updates
n/a
Request form download
Consent record
See consent guidance in test request form
Sample requirements
Sample Requirements Each sample must be sent labelled with 3 patient identifiers and must state the sample type clearly on the sample container. Sample Rejection Samples may be rejected for the following reasons: 1. Samples and request form do not show at least three identical patient identifiers 2. The sample is in the incorrect collection media 3. The request form is not sufficiently completed 4. The sample is not of sufficient volume 5. The sample is too old Sample Storage and Volume Required: Placenta, fetal tissue sample, umbilical cord, as available, in a dry sterile container. Storage, sample packing and transportation: Dry, sterile, air-tight container without fixatives or preservatives. Skin biopsies or small samples of other solid tissue should be placed in a standard tissue culture medium. Patient/Clinician Instructions: Patient information and consent: Please ensure patient consent is obtained prior to the sample being sent to the laboratory for SNP microarray (please note patient consent forms should be stored and should NOT be sent to the laboratory). Referral information required: Referral form with detailed clinical information to support R318 or R22 Factors affecting performance of test/interpretation of results: DO NOT FIX IN FORMALIN.